From Earlham Cluster Department
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S,T & S Final Research Paper: Depression
The aim of this paper is to synthesize and summarize the current information and discourse about depression through the lenses of science, technology, and society. Though the paper has been structured in such a way as might suggest that these three categories could stand on their own, what should become evident is that, while it is possible to address them separately, there are beneficial insights to be gained by addressing them jointly. Science (what we know about depression), technology (the tools we use to work against the problems it causes), and the society (for our purposes, the cultural and economic forces that surround, interact with, act upon, and respond to science and technology), all influence each other. As depression becomes more and more widely diagnosed, especially in higher-income nations, what scientists understand about it and how we go about treating it is becoming more and more important.
Science: What is Depression?
What is colloquially referred to as depression is actually classified by the Diagnostic and Statistical Manual of Mental Disorders IV as several different mood disorders. A mood disorder is a mental disorder in which the root cause of symptoms is extreme, or extremely limited, mood outside the range considered healthy and normal . The two main forms of mood dysfunction are mania, an abnormally elevated or irritable mood  and depression, an abnormally or abnormally extended low mood . Some mood disorders are the result of just one or the other of these conditions, while others result from a combination of the two. Bipolar disorder (previously know as manic depression)is one of the later. Disorders that result from depressive mood include major and minor depressive disorders, dysthymia, and seasonal affective disorder.
Because of the wide variety of causes and symptoms underlying various depressive disorders, their classifications can be difficult to pin down. It is important to keep in mind that these are the most common presentations and that there are other disorders that may be considered to fall into the category of depression. A patient may have a disorder that does not neatly fall into one of the categories below.
Major and Minor Depressive Disorders
Major depression, also referred to as clinical depression, is a case of chronic, long-term depression that can heavily interfere with a person's ability to function in day-to-day life . Minor depression is sometimes used to describe a less severe case of depression.
Dysthymia and Atypical Depression
Dysthymia is a milder depressive episode that usually last for two years. While the symptoms of dysthymia are less severe than the symptoms of major depressive disorder, dysthymia can be just as, if not more, disruptive and harmful to a person's life because of its chronic nature. People displaying symptoms of dysthymia may seem to complain constantly, be overcritical, and have difficulty having fun or enjoying themselves. 
Atypical depression in also a chronic condition, with symptoms that are usually milder than those of major depressive disorder but much more prolonged. Atypical depression often begins during teen years and continues into a person's adult life .
Seasonal Affective Disorder
Those Seasonal Affective Disorder, SAD, experience symptoms of depression only during certain times of the year. Usually, depressive episodes begin in the fall and end as spring begins, however there have been cases of SAD in which the symptoms of depression present in the spring and summer months. In addition to the treatments applied to other forms of depression, SAD is also treated with light therapy, to be discussed in the technology section of this paper.
It is important to realize that the reason depression is classified as a mood disorder is because mood itself is the underlying cause of the symptoms displayed. Depression can be a symptom of other mental or non-mental diseases, such as mononucleosis or the early onset of Alzheimer's , and this can lead to complications in diagnosis. However, it is important to recognize depression as a real and serious mental illness that can deeply impact a person's ability to cope with day-to-day living.
The most typical symptoms of depression include loss of interest in formerly enjoyable activities, apathy, inexplicable sadness, low energy, loss of appetite (or, conversely, weight gain), interrupted sleep, guilty feelings, low self-esteem, and poor concentration . Atypical depression often causes a sense of heaviness in the limbs and oversleeping. People with severe cases of major depressive disorder can have difficulty finding the motivation to get out of bed for days at a time, and the most serious cases of depression can lead to suicidal thoughts and suicide.
Depression can have other, perhaps more subtle, effects on interpersonal and social skills. As previously mentioned, people with dysthymia tend to be overcritical of peers and co-workers and have difficulty having fun, which heavily impacts their ability to socialize with others and can damage existing relationships. Those suffering from atypical depression often fear rejections by others and have trouble forming or maintaining relationships as a result .
The illnesses referred to as depressive disorders are known as such because the cause of their symptoms is depression. Because of the complex nature of mental illness, it is often hard or even impossible to name a single and specific cause of that illness within a patient, and depressive disorders are no exception. Genetic, life event, and chemical factors can all play a part, and may all be contributors to illness in a single person. The risk factors for depression include a family history of depression, grief due to a death or major loss, personal conflicts, major life events -- even positive ones, serious or long term pain or illness, certain medications and substance abuse (21).
Chemicals in the Brain
A popular hypothesis amongst drug manufacturers is that depressive disorders are caused by imbalances in serotonin or nor-epinephrine in the brain. These are neurotransmitters, chemicals that are produced by neuron cells. Neurons are form networks in the brain and nervous system via connections called synapses(22), which are specialized gaps between cells that permit the transference of information between neurons by electrical and chemical signaling. What this means is that chemicals like serotonin and nor-epinephrine cross the synapse -- the gap between cells -- when the neuron cell is stimulated, and a receptor cell on the other side receives the chemicals, where they produce a biological effect. The image below is a simplified diagram that shows neurotransmitters crossing the synapse to a receptor cell on the other side.
Also shown in the diagram is the phenomenon of reuptake. When a neurotransmitter is released across the synapse, some of the molecules will be taken back in by the firing neuron rather than the receptor cell. The serotonin hypothesis states that depression is caused by a lack of serotonin in the brain, so reuptake will be discussed again in the portion of this paper that covers antidepressant medications.
Although the neurotransmitter imbalance hypothesis is widely known to the American public because of advertisements for antidepressant drugs, it has recently been called into question. Scientists and researchers are pointing out that it has never actually been confirmed, and more and more evidence is beginning to say that the hypothesis is not valid. Scientists have not actually been able to identify a specific level of serotonin or nor-epinephrine that is "correct" for most people, and tests that deprive the brain of serotonin or introduce more into it have been largely inconclusive.
Genetics and Heredity
Scientific studies have determined that symptoms of depression are heritable, meaning that a person is more likely to display symptoms of depression if their family members do (37). If depressive disorders can be inherited, then genetics must play a part in the likelihood that a person will experience a depressive episode. Many different research approaches have been taken to try to account for the genetic influence on mood disorders. Recently, a research article was published that identifies 169 genes that have a high correlation with depression (38). Modern technology has allowed scientists to identify the genetic code in thousands of DNA samples. By the comparing of such samples with the characteristics of the people they come from, researchers were able to identify from a list of thousands those genes that were most likely to be related to depression. They found that most of these genes are expressed in human brain and nerve tissue, a fact that supports the hypothesis that neurotransmitters play a role in the cause of depression. However, the large number of genes that could possibly be influencing a person's tendency towards developing a depressive disorder suggests that the issues is far more complex than simply the amount of serotonin or dopamine in the brain (38).
This is a prime example of the way technology is able to inform science. Rather than using technology to look at genes already suspected to contribute to depression, this research involves using technology to collect new data that can be transformed into new scientific information.
Other Causes to Consider
While genetics and brain chemistry are certainly factors which can cause depression, it is important to note that social and cultural conditions can also play an important role. Below is a map showing the prevalence of variants of the serotonin transport gene (SERT) that are associated with depression. The scale on the left denotes the percentage of the population who posses these variants represented by the colors on the map.
Now, see the distribution of people who have been diagnosed with a mood disorder. The scale on the left denotes how the colors on the map represent the percentage of people in each country who have been diagnosed.
While the potential for a mood disorder can be seen in the genetic code, how that code presents phenotypically seems to be influenced by other factors. The above images come from a paper by Chiao and Blizinsky, a Northwestern University psychologist and her graduate student, published by the Royal Society in 2009. They concluded that while misdiagnoses might account for some of the discrepancy that can be seen in these two maps, it cannot account for all, and that cultural factors are clearly at play in this comparison.
Technology: What tools do we have to fight depression?
Science has determined the existence of depressive mood disorders, has cataloged their causes and symptoms, and continues to develop a body of knowledge surrounding the physical, emotional, chemical, and genetic aspects of depression. Scientists and medical practitioners have developed technologies to deal with depression on a practical level. Diagnostic and treatment methods have been developed that can significantly improve the quality of life of a depressed patient and even save patients' lives, and all but the most severe cases of depressive disorders can be fully recovered from when given appropraite attention.
It is important to keep the distinction between science and technology in mind during the discussion of treatment for depressive disorders. It will become clear as a description of treatment methods unfolds that, while the technology of treatment uses the knowledge that science provides for it, it also effectively uses tools and methods for which science cannot provide a solid explanation. The benefits of exchange between science and technology, as well as the misunderstandings it might produce, are made clear in the example of depressive disorders and their treatment.
A standard process for the diagnosis of mood disorders, including depressive disorders, is laid out in the Diagnostic and Statistical Manual of Mental Disorders IV. It has been refined through previous editions and that process will continue as new editions are produced . There are also a variety of tests and questionnaires that have been developed that try to determine the severity or type of depression that a patient is experiencing. Since depression is not only a mental disorder, but can also be the symptom of other illnesses, the first steps of the diagnostic process involve ruling out other causes of depressive symptoms. The complexity and variety of causes and symptoms of depressive disorders mean that the process of diagnosis must often be coupled with careful experimentation in the area of treatment. This means that after a diagnosis is given, it is still important that a patient continues to have a dialog with his or her healthcare professional in order to adjust treatment appropriately.
The two most effective and well-tolerated tools with which we can treat depressive disorders are psychotherapy and medication. According to the World Health Organization, a combination of anti-depressants and "brief, structured forms of psychotherapy" is successful in 60-80% of cases. As previously mentioned, light therapy is helpful for those afflicted with SAD. In severe cases of depression for which faster improvement is deemed necessary for the health and safety of a patient, electroshock therapy is sometimes employed.
Talk therapy or counseling can be a highly useful tool in the treatment of depression, and most doctors recommend that it should accompany any other treatments a patient might undergo. There are a variety of strategies that a therapist might employ, most involving encouraging a patient to examine patterns of thought and behavior, and providing them with techniques to reframe or alter these patterns. The National Institute for Clinical Excellence has advised that non-pharmacological treatment methods are the best approach in treating cases of mild depression. A study released in the Archives of General Psychiatry has found that for moderate to severe depression, 16 weeks of cognitive therapy was equally effective across a test group as 16 weeks of treatment via medication, although the experience and expertise of individual therapists is admitted to be an important factor in the efficacy of such therapy (31). The rate of relapse was slightly lower for patients undegoing therapy than for patients undergoing pharmaceutical treatment -- 40% versus 46% respectively (31).
The most well-known and commonly prescribed antidepressant medications currently available are SSRIs -- selective serotonin re-uptake inhibitors. As mentioned previously, some scientists have hypothesized that imbalances of the neurotransmitter serotonin contributes to depression. SSRIs do exactly what their name says; they prevent the reuptake of serotonin by neurons that release it, increasing the amount of serotonin being transmitted in the brain. Some well known SSRIs include fluoxetine (Prozac), sertraline (Zoloft), escitalopran (Lexapro), and citalopram (Celexa), and there are a few others. These medications are FDA approved to treat a variety of disorders from depressive disorders to obsessive-compulsive disorder, social anxiety disorder, and premenstral dysphoric disorder.
Although their name seems to imply that the inhibition of serotonin reuptake is what eases depression in the patients taking these medications, the scientific community is actually uncertain as to whether or not this is the case. It takes only hours for SSRI medications to affect an increase in serotonin levels in the brain, but a patient must take a medication for several weeks before they begin to feel an ease to their depression